We reviewed and summarized the technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain.
Vandekerckhove, Bram, Jeroen Missinne, Kristl Vonck, Pieter Bauwens, Rik Verplancke, Paul Boon, Robrecht Raedt, and Jan Vanfleteren. 2021. “Technological Challenges in the Development of Optogenetic Closed-Loop Therapy Approaches in Epilepsy and Related Network Disorders of the Brain.” MICROMACHINES 12 (1). doi:10.3390/mi12010038. 

We measured (using a Fiber Bragg Grating sensor) and simulated the increase in brain temperature upon illumination with blue light at different irradiance values.
Acharya, Anirudh R., Bram Vandekerckhove, Lars Emil Larsen, Jean Delbeke, Wytse J. Wadman, Kristl Vonck, Evelien Carette, Alfred Meurs, Jan Vanfleteren, Paul Boon, Jeroen Missinne, and Robrecht Raedt. 2021. “In Vivo Blue Light Illumination for Optogenetic Inhibition: Effect on Local Temperature and Excitability of the Rat Hippocampus.” JOURNAL OF NEURAL ENGINEERING 18 (6). doi:10.1088/1741-2552/ac3ef4.